Features & Benefits
Sixty healthy beagle dogs took part in a controlled, randomized, masked Good Clinical Practice (GCP) study. Thirty dogs were given StrixNB treated drinking water, and thirty dogs received no StrixNB in their water, as they formed the control group. At the beginning of the study all of the dogs had their teeth cleaned. On day 0, the calculus of each dog was scored. The dogs then drank the treated StrixNB water at the recommended dose for 84 days. The calculus was scored on days 28, 56, and 84. The mean calculus scores for the StrixNB treated dogs were lower than the control group for the duration of the study.
The calculus score for the StrixNB treated dogs was 25.4% lower than the control group. The difference between the two groups was significant (p<0.03). The study demonstrated that StrixNB is effective in preventing dental calculus in dogs.
To determine the safety of StrixNB water additive in dogs, a controlled, randomized Good Scientific Practice (GSP) study was performed. The study was conducted over 30 days with one control and two treatment groups which received 1X or 5X the recommended StrixNB dose.
Clinical observations, oral assessments, body weight measurements, and clinical pathology analysis were performed during the study. Dogs were observed daily for food intake, general appearance, and feces. Bi-weekly body weight measurements were taken, and samples for blood, serum, and coagulation were collected on days 1, 14, and 29.
Clinical observations, physical exams, and oral assessment revealed no evidence of adverse effects related to the consumption of StrixNB. The study demonstrated the safety of StrixNB water additive at 1X and 5X’s the recommended dose.
Sodium Citrate – A chelating agent.
Citric Acid – pH buffer to ensure there is no change to the pH balance in the animal’s mouth.
Zinc Chloride – A mineral able to bind to volatile sulfur compounds which reduces bad breath.
NON MEDICINAL INGREDIENTS
Potassium Benzoate – Preservative approved and required by Health Canada.
Disodium EDTA – Preservative approved and required by Health Canada.
Biofilms are structured communities of microorganisms enclosed in a matrix of complex sugars, or polysaccharides. About 99% of all bacteria live in biofilm communities. These communal bacteria are 100 to 1000 times more resistant to antibiotics and antimicrobials compared with their planktonic counterparts.
A pet’s saliva along with any food debris on their teeth contain magnesium, calcium and iron – the food source for bacteria.
As bacteria is attracted to this food source, it attaches to the tooth’s surface and produces a protective dome called a biofilm, under which the bacteria rapidly multiply to create a colony. This yellow, gooey substance is plaque.
After a while some bacteria will break free to start other colonies, which progresses the formation of plaque.
Eventually the plaque calcifies and turns into an extremely hard substance called tartar. Bacteria continue to build layers of plaque and calcified tartar.
When StrixNB enters the pet’s mouth, its binding agents immediately attach to the magnesium, calcium and iron, and wash them away – effectively removing the bacteria’s food source and weakening the tartar.
Without this food source the bacteria have nothing to live on and colonies become weak. Eventually the layers of plaque and tartar buildup begin to soften. The tartar can then easily flake and break off.